We have over 20,000 different genes in the body, and those genes are located in our DNA. These genes are like instruction manuals for how to build a protein, and each protein has an important function that helps to keep our body working how it should. The BRCA1 gene makes a protein called the BRCA1 protein. As we go through life, our DNA can get damaged in many different ways, including exposures in the environment, or when our cells are dividing to make new cells. Sometimes this damage happens due to causes that we do not yet know about. As this damage builds up, it can cause a cell to grow out of control. This can lead to a tumor, which can then lead to cancer. The BRCA1 protein works with other proteins to fix this damage that happens in the DNA, thus preventing the cells from growing out of control. Repairing this damaged DNA helps to prevent tumors from forming.
If someone has a harmful change (called a pathogenic variant) in one of their BRCA1 genes, then their body does not make as much BRCA1 protein as it should. Without enough BRCA1 protein, our body can not repair our damaged DNA as well as it should be able to. This can allow the damage to build up in cells more quickly, which causes the increased risk for BRCA-related cancers. Someone with HBOC is not producing enough BRCA1 protein from birth, which is also why people with HBOC can be diagnosed with these cancers at an earlier age than would normally be expected.
There are increased risks for certain types of cancer in individuals who have a pathogenic variant in the BRCA1 gene, although the associated cancers and lifetime risks are different between men and women:
|Cancer type||General population risk||Risk with pathogenic variant in BRCA1|
|Second female breast||1.5% per year||Up to 20% within 5 years|
|Male breast||0.1%||Risk increased|
Pathogenic variants in the BRCA1 gene are inherited in an autosomal dominant pattern, meaning that children of someone who has a pathogenic variant in BRCA1 have a 50% chance to inherit the variant and associated cancer risks. Notably, women and men both have the BRCA1 gene and have the same chances to inherit and pass down pathogenic variants. Therefore, both sides of the family are important when assessing inherited risk. Almost all people who have a pathogenic variant in BRCA1 will have a parent who also carries it.
Genetic testing for pathogenic variants in BRCA1 has been available for many years, and the testing methods have changed and improved over time. There are several different ways to approach testing depending on the medical and family history, and any prior testing that may have been done. Different approaches include:
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